What are the Health  Benefits of Forskolin
Forskolin is a member of the mint family also called Coleus Forskohlii.The chemical structure of this plant is joined naturally by two rings. This plant is a perennial herb with fleshy fibrous root from the coleus forskolin plant and has been known to man for centuries. It is found in Africa and Asia which root and leaves are used for cuisines and for different ailments such as urinary tract, hearts, lungs, glaucoma, obesity asthma, and other range of health conditions.http://
  1. Fat Burning, Promotes weight loss
Some prefer the unconventional way of losing weight. Forskolin supplements have been used to burn fats. Studies on 30 overweight and obese persons that were given 250 milligrams of forskolin twice daily or a placebo on a 12 week period, show that those who take the forskolin supplement gained more bone mass and burned 7 to 8 times more body fats when compared to the other placebo group. Forskolin is said to stimulate the release of stored body fats. However, like most weight loss substances, this can be made possible when your calorie intake, energy must be less than your calorie out, energy expenditure. Further studies are still on to ascertain or conclude forskolin’s ability to reduce weight as it is believed to be with many people. Forskolin may have helped prevent weight gain instead of helping to accelerate weight loss.
The compound cAMP which comes from adenosine triphosphate (ATP) (2) in Forskolin activates ( AC-III) an enzyme adenylyl cyclase. This enzyme regulates human cells. It enables the transfer of messages from the outside of the cell to the inside.
 2.Forskolin increased .http://testosterone level
One study in men indicates that it may increase testosterone levels and improve body composition, as in making you lose fat while increasing muscle mass, A rise in testosterone increases muscle mass( 6 trusted source). The compound cAMP in Forskolin activates ( AC-III) an enzyme adenylyl cyclase. This enzyme regulates human cells. It enables the transfer of messages from the outside of the cell to the inside. Research in a white rabbit model found that injection of forskolin resulted in changes (relaxation of smooth muscle) which could help with erectile dysfunction. The same experiment team then injected forskolin into the blood vessels of the penis of 31 men with erectile dysfunction, it was found that there was an improvement in rigidity in 61% of the participants.
3. Helps to prevent Glaucoma
Forskolin properties may help in the prevention of glaucoma. It promotes the stimulation of (AC-III) and by so doing helps in the prevention of glaucoma. 2013 studies confirmed that the compound in forskolin, rutin reduces eye pressure by 10%. And that the higher the doses the higher the decrease in eye pressure thereby preventing the chance of developing glaucoma
4. Helps in the treatment of Asthma?
Studies that involved 40 adults taking orally 10 milligrams of capsules per day or two inhalations of sodium cromoglycate every eight hours, that is three times a day for six months concluded that forskolin compared favorably better than sodium cromoglycate medication on patients with asthma. The biological possibility of forskolin inhibiting or managing asthma is still a debatable point as the evidence available are still very limited. Forskolin should not be used as the first line of treating asthma attack.
Other ailments for which Forskolin is used to manage :
5. High blood pressure
6. Urinary tract infection
7. Eczema
8. Menstrual pain
9.Psoriasis
10.Thyroid
11.Increases bone mineral density, thereby lowering the risk of osteoporosis (6Trusted Source).
12.Insomnia
13. Improved respiratory function
Studies on patients with respiratory problems show that routine use of forskolin improves their overall respiratory functions as it widens the air passages in the lungs.. Forskolin functions in the same way to many asthma drugs by increasing the level of a compound ( cAMP) cyclic adenosine monophosphate (cyclic AMP). And by increasing this compound relaxes the air passages and decreases the risk of respiratory spasms.
14. Can Forskolin treat Alzheimer ?
Forskolin activation of cAMP could inhibit cholinesterase which plays an important protective part in Alzheimer’s disease.
. There are 58 pre-clinical studies that indicate that it may be helpful. Studies in 1998 suggested that increasing cAMP can help aid memory loss in mice. This study did not use forskolin as the agent to increase cAMP but used another agent called rolipram. The significance of this study is that it provides a biological ground by which forskolin could assist with memory. And more studies like this are required especially on humans, so as to enable us to conclusively assert the importance of forskolin in treating Alzheimer
Also, research in 2017 showed that forskolin could reverse memory loss in mice who had been treated with streptozocin to induce dementia.
Likewise, studies in 2018 indicated that forskolin can affect a protein called tau and as such could have beneficial effects in Alzheimer’s disease.
Colforsin which is a water-soluble form of forskolin was introduced directly into the cerebral arteries of 29 patients. The 29 patients went through a total of 53 procedures. improvement was noticed in 86% of cases and 66% of patients were seen to have a good recovery.
. In all these studies there is no conclusive evidence indicating that forskolin can treat Alzheimer.
14. Forskolin as an anti Cancer agent
With Forskolin an enzyme called adenylate cyclase enzyme increases the level of cAMP from ATP. And as the level of cAMP rises in cells,this plays a key role in regulating cancer cells. Three different studies revealed forskolin as an anti-cancer agent. A study from 1983 looked at the effect of forskolin impact which is a lung cancer cell line that likes to metastasize in the lungs. The researchers injected forskolin into the tail of mice and then injected the lung cancer cells into the mice. They found that forskolin inhibits the lung cancer cells by about 70% in all three different experiments.
Studies also show that forskolin may decrease the side effects of chemotherapy on those who participated in the chemotherapy experiment. It must be noted however that science has not conclusive assert that forskolin can treat cancer
15. Forskolin for skin tanning?
Studies in the U.S. melanoma researchers found that forskolin cream could cause tanning in fair-skinned individuals which could also protect against UV damage. This study may need further research as it has not been tried out in humans.
Side Effects. Is Forskolin Safe
Extensive research is still needed to know the several beneficial effects of forskolin medically, as it is not scientifically concluded as to the safety of forskolin. Forskolin supplements are safe to be taking. There have been some side effects to some people. Sides effects such as
Low blood pressure
Cough
Headache
Fast heartbeats, slow heart rate
Flushing, diarrhea.
Restlessness when inhaled
Stinging of the eyes Forskolin Supplement Safe?
it is generally noted that Forskolin may cause genotoxic effects in some people and further evaluation on its overall safety is still needed
When to Avoid Forskolin
Patients with polycystic kidney disease, and persons taking Anticoagulants (“blood thinners”) like Coumadin (warfarin)
Antiplatelet drugs like Plavix (clopidogrel) should avoid Forskolin.
Women who are pregnant or breastfeeding and children should consult with their doctors before taking forskolin or its supplements..
People taking medications for high blood pressure and other blood thinners or medicine like hydralazine, Clonidine, and calcium substances should avoid taking forskolin.
A patient that is to undergo surgery is advised to stay away from forskolin as it may increase bleeding tendencies.
In Conclusion
Forskolin has been known to man for centuries. In modern times Forskolin is made available in gels, liquid, capsules, and powder. And are found in online stores, Pharmacies, or stores that sell natural foods. Never take more than the recommended doses on the label. Typical doses of 100 to 250 ml, twice a day is the recommended dosage. Some doctors also use this herbal medicine through the vein, or intravenously, for the treatment of heart failure. In the treatment of respiratory disorders like asthma, its powdered form has been used for inhalation. Forskolin’s medical benefits as alternative medicine are still under study just like intermittent fasting for weight loss. It must be noted that forskolin does not have adverse effects on humans and there is no denying the fact that forskolin has some medical benefit.